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KMID : 0984920130150020106
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Journal of Skin Barrier Research
2013 Volume.15 No. 2 p.106 ~ p.106
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Clinical Evaluation and Application of New Biological Antibacterial Moisturizer in Atopic Dermatitis
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Kong Tae-Seok
Han Tae-Young
Lee June Hyunkyung
Son Sook-Ja
Shin Moon-Sam
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Abstract
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Patients of atopic dermatitis (AD) are highly susceptible to colonization by various bacteria, including staphylococcus aureus (S. aureus). Triclosan is a lypophilic chlorophenol biocide with broad-spectrum antibacterial activities. The aims of this study were to assess the efficacy of a moisturizer containing triclosan compared with the moisturizer alone (vehicle) for the treatment of AD. In total, 30 patients with mild to moderate AD instructed to apply the study cream and vehicle on each antecubital fossa. Patients were assessed for severity according to the SCORAD. Skin barrier function was checked by corneometer, transepidermal water loss and acidity. S. aureus was sampled on each antecubital fossas using by contact-plate sampling technique. Evaluation were performed at week 0 (baseline), 2nd and 4th. At week 2, there were significant decrease in SCORAD and improvement of skin barrier function from baseline for the study cream. And the number of S. aureus colonies was statistically decreased from baseline. At week 4, the severity of AD and skin barrier function were also improved with continuous using of study cream. And there was more decreased the colonization of S. aureus comparing with week 2. This study demonstrates that topical application of triclosan-containing moisturizer reduces the colonization of S. aureus of the patients with AD. Moreover, the severity of AD and skin barrier function were improved with treatment.
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